Prevention of Incontinence

Comparatively little is known about the prevention of incontinence. For this reason the Continence Foundation joined the CONTINENCE PROMOTION COMMITTEE of the International Continence Society and the SIMON FOUNDATION FOR CONTINENCE in the USA to sponsor an international consensus conference on the subject in June 1997. The conference was made possible by an educational grant from Pharmacia Ltd.
CONSENSUS STATEMENT PUBLISHED AFTER THE CONFERENCE
LIST OF INVITED PARTICIPANTS
 
CONSENSUS STATEMENT
FIRST INTERNATIONAL CONFERENCE FOR THE
PREVENTION OF INCONTINENCE
DANESFIELD HOUSE U.K. JUNE 25-27 1997
INTRODUCTION
A: CLINICAL DEFINITION
B: THE CONCEPT OF PREVENTION
C: HEALTHY BLADDER HABITS
D: INCONTINENCE PREVENTION BY AGE GROUP
    - PREVENTION IN CHILDHOOD
    - PREVENTION IN YOUNG ADULTS
    - PREVENTION IN THE MIDDLE YEARS
    - PREVENTION IN HEALTHY OLDER ADULTS
    - PREVENTION IN FRAIL OLDER ADULTS
E: PROMOTING PREVENTION EDUCATION BY TARGET GROUP
Introduction
A two day conference was convened at the Danesfield House U.K. with the intent of creating a Consensus Statement which would guide and direct future clinical practice and research for the Prevention of Incontinence.

First conceived during discussions of the Continence Promotion Committee at the 1996 ICS (International Continence Society) meeting in Athens it was through the outstanding initiative of The Simon Foundation for Continence (USA) and The Continence Foundation (UK) that the First International Conference for the Prevention of Incontinence (P97) was realised.

Forty two internationally recognised experts in the field came together to examine and critique current research. Rigorous intellectual debate followed each of the dozen presentations.

The dynamic interaction and collaboration of panel, presenters and expert audience was as stimulating as it was productive. Pieces of the prevention puzzle emerged as presentations and debates progressed.

This Consensus Statement is the outcome of these two days in June.

Special mention is due Dr. Alan Cottenden, panel chair, and conference co-chairs Cheryle Gartley, Christine Norton and Anita Saltmarche for their substantial contributions to this endeavour.

Without an educational grant from Pharmacia & Upjohn, and the personal sacrifice and professional commitment of all participants the P97 conference would have remained an idea in Athens.

This Consensus Statement was first issued at the 1997 International Continence Society meeting in Yokohama, Japan.


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A CLINICAL DEFINITION
URINARY INCONTINENCE


Since there are numerous definitions of Urinary Incontinence, it was agreed that the International Continence Society definition be adopted by the Conference.

Urinary Incontinence 'is a condition in which involuntary urine loss is a social or hygienic problem and is objectively demonstrable'. However, the 'objectively demonstrable' criteria may require modification in large-scale epidemiological work.

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B THE CONCEPTION OF PREVENTION
While there are different models of prevention, the following definitions related to prevention were used as points for discussion. It was noted that these definitions are embedded in a disease model.

PRIMARY PREVENTION

Preventing disease from occurring by removing its causes.

SECONDARY PREVENTION

Detecting asymptomatic disease early and treating it to stop progression.

TERTIARY PREVENTION

Activities that prevent deterioration or reduce complications after a disease has declared itself.

THE IMPAIRMENT-DISABILITY-HANDICAP MODEL


Recognising that incontinence is not a disease but is a symptom or condition the panel felt it may be necessary to consider a prevention model similar to the Rehabilitation model of Impairment~Disability-Handicap. Using this model, impairment would be the underlying bladder or sphincter dysfunction (or dysfunction of the neurological control system at any level). Disability would be the consequent symptom of incontinence. The limitations imposed on the individual's quality of life are the handicap. Therefore, primary prevention would be aimed at preventing the underlying impairment from developing. Secondary prevention would be preventing the individual, despite an underlying predisposition, from becoming incontinent. Tertiary prevention would be preventing incontinence from worsening, or causing complications (such as skin problems) or limiting the impact of being incontinent upon the individual and those around them.

QUALITY OF LIFE

Quality of life was a recurring theme at the conference. Although the concept is frequently addressed in research, it is often not clearly defined. It was agreed that the outcome of any prevention strategy should be assessed not only in terms of bladder function, but also should incorporate the individual's perspective. Quality of life outcomes need to include overall benefits to both the individual and society as a whole. It was recognised that prevention programmes are likely to be costly. Consequently, future prevention research should consider a cost-benefit analysis.

It was agreed that the focus of this meeting should be on primary and secondary prevention as treatment and containment are discussed and researched elsewhere. It was further agreed that some primary prevention measures, such as those aimed at preventing neurological disease or injury (with subsequent incontinence) were beyond the scope of this conference.

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C HEALTHY BLADDER HABITS
P97 participants agreed that the promotion of prevention is essential and therefore developed these recommendations.

Drink Adequately:

6-8 cups of fluids per day, more when it is hot or when exercising.

Recognise that:

Most people empty the bladder about every 3-4 hours during the day ( 4-8 times in 24 hours). Getting up once at night to empty the bladder is not abnormal. Being awakened more than twice is abnormal.

Relax:

Don't strain to empty the bladder or the bowel.

Try to keep bowel movements regular:

Don't ignore feelings that the bowels need emptying.

Seek professional help when:

Any leakage of urine from the bladder occurs (incontinence). Pain is experienced when passing urine. Any blood is seen in urine.

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D INCONTINENCE PREVENTION
         BY AGE GROUP

      PREVENTION IN CHILDHOOD
Clinical Evidence
Indicates what is known about preventing incontinence.

Acquisition of general continence abilities are probably innate in neurologically intact humans.

Toileting skills and behaviour that are learned, have a certain plasticity, and vary across cultures.

Although there are undoubtedly many cultural influences on the acquisition of toilet skills, we do not have much evidence of the effect of these on later bladder habits and contin
ence.

There is little evidence that adults with bladder problems pass on abnormal patterns to their offspring. We do not know if these have an impact on the genesis of later dysfunction.

Genetic research has identified a marker for one type of nocturnal enuresis, but not as yet for other bladder dysfunctions.

It is shown that children with severe mental retardation can often acquire continence if systematically trained using behaviour techniques.

Urinary tract infection in childhood should be investigated and appropriately treated as there may be long-term adverse sequelae.

Schools and teachers need to promote positive attitudes to toileting and to promote an open positive culture about bodily functions.

The value of preventive pelvic floor education or bladder awareness in schools is unproven.

Children with congenital or acquired neurological impairments are not inevitably incontinent if a systematic planned approach is implemented early.

Research priorities
Not in order of priority.

Environmental influence on the acquisition of toileting skills

Longitudinal studies to determine the effect of early training or childhood dysfunction on continence in later life

Inter-relationship of skills for bladder and bowel continence

PREVENTION IN YOUNG ADULTS
Clinical Evidence
Indicates what is known about preventing incontinence.

Constipation, obesity, smoking and some medications (e.g. alpha blockers, caffeine and diuretics) may be risk factors.

Asymptomatic bacteriuria is not linked to incontinence.

Adults with neurological disease often have inevitable bladder or sphincter impairment, but active management may prevent this manifesting as incontinence.

For women, the major risk factor is undoubtedly vaginal delivery during childbirth.

Caesarean section appears to prevent incontinence, certainly for the first baby, possibly less so for multiple births.

Vacuum extraction rather than forceps is preferred for assisted delivery to prevent incontinence.

The relation of episiotomy to incontinence is unclear.

There is weak evidence that antenatal pelvic floor exercise may be protective in the postnatal period. Longer term benefit is unproven.

Excessive physical stress during exercise or repeated lifting may be a risk factor in the development of incontinence in women.

Young men are a low risk group for incontinence (with the exception of nocturnal enuresis).

Research priorities
Not in order of priority.

Prospective studies of risk factors in continent women (including further work on caffeine, medications and obesity).

Further study the effect of childbirth practices such as episiotomy and assisted delivery on long-term continence.

Further study on the effect of pre- or post-natal pelvic floor education and exercise.

Study the effect of exercise and lifting on the pelvic floor.

Prospective study of the effect of constipation in continent females.

Methods to improve bladder emptying and prevent complications in patients with neurological disease (e.g. does the Crede manoeuvre create long-term problems?)

PREVENTION IN THE MIDDLE YEARS

Clinical Evidence
Indicates what is known about preventing incontinence.

Radiotherapy for pelvic malignancies is associated with increased urinary incontinence.

For women the link with vaginal delivery becomes less clear than in younger women.

The role of oestrogen and menopause is likewise unclear. It is not known if hormone replacement therapy (HRT) helps to prevent the development of urinary incontinence.

Urinary incontinence is clearly linked to obesity in women.

The role of smoking is less clear, as is the role of hysterectomy and of straining due to chronic constipation.

Sometimes repair of a vaginal prolapse can unmask a tendency to urinary incontinence.

Incidence of incontinence in women tends to level off with advancing years; stress incontinence may even decrease with age. Only when dementia, immobility or general frailty develop does the prevalence increase with age.

Men continue to be a low risk group, until the age where the prostate becomes troublesome for some and may need intervention.

Radical prostatectomy is associated with urinary incontinence. Specialised centres should be developed for the treatment of prostate cancer (performing more than 20 operations per year), and men need improved information about incontinence risks to enable an informed choice on intervention.

Pre-operative detrusor dysfunction may make urinary incontinence more likely after transurethral resection of the prostate (TURP).

Post-micturition dribbling can often be prevented by simple education.

In men with symptoms suggestive of prostatic hyperplasia and coexisting Parkinsonism, particular care should be taken not to misdiagnose Multiple System Atrophy (MSA) as Parkinson's disease. Removal of the prostate is inadvisable in men with MSA.

Research priorities
Not in order of priority.

Prospective study of the effect of hysterectomy on bladder function.

Long-term effects of childbirth, including obstetric practices and age of childbearing.

Study further the role of collagen.

Investigate the effect of menopause and hormone replacement therapy on the urinary tract.

Study the effects of prolapse and its repair, other pelvic surgery, and continence.

Long-term sequelae of untreated obstruction or its medical management in men.

Prospective study of pre-operative risk factors and continence after prostatectomy.

Development of a standardized outcome questionnaire, including continence status, to be used with patients undergoing radical prostatectomy. Comparison of continence results from different surgeons and centres.

PREVENTION IN HEALTHY OLDER ADULTS

Clinical Evidence
Indicates what is known about preventing incontinence.

Investigated Risk Factors

Previous genito-urinary surgery.

Impaired mobility.

Chronic cough.

Functional disability.

Stroke.

Respiratory illness.

Sedatives and hypnotics.

Faecal incontinence or impaction.

Current research has not proven the importance of:

bacteriuria without dysuria, caffeine, alcohol, race, ethnicity.

It was noted that studies have largely been cross-sectional and have not fully considered the effect of confounding factors.

Research priorities
Not in order of priority.

Prospective longitudinal study of these risk factors.

Relationship of urinary and defaecation problems.

Effect of general fitness and mobility.

PREVENTION IN FRAIL OLDER ADULTS

Clinical Evidence
Indicates what is known about preventing incontinence.

The prevention model outlined in section B. is not appropriate for many frail older adults who are dependent on caregivers for toileting and maintaining continence. Therefore the concept of "Dependent Continence" is most applicable.

Investigated associations include:

Immobility

Impaired cognition, especially spatial

Drugs, particularly sedatives and diuretics

Complexity of physical environment and barriers (e.g. the number of points where the individual must make a decision on the way to the toilet)

Impaired activities of daily living, particularly dressing dependence

Caregiver attitudes/beliefs/knowledge

Disease e.g. Parkinson's, CVA, diabetes, fractured neck of femur

Retention of urine or an elevated post-micturition residual: urologic causes or post-operative.

Research priorities
Not in order of priority.

Does identification of co-morbidity lead to improvement?

What are clinically (as opposed to statistically) relevant outcomes for this group?

Measurement and modification of caregiver attitudes/knowledge/ expectations and how to change them, with what clinical effect?

Why some individuals with increased risk become incontinent while others maintain continence.

Catheter management.

Retention and its relevance.

Minimising impact on quality of life for intractable incontinence.

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E PROMOTING PREVENTION EDUCATION
      BY TARGET GROUP

GENERAL PUBLIC


The panel agreed that extensive education across the following target groups was necessary to promote prevention of incontinence.

The general public should be informed about healthy bladder habits and when/how to seek help.

Parents should know about the possible effects of toilet training practices and attitudes.

Teachers and schools should be informed about the importance of healthy bladder habits and appropriate toilet environments.

People with neurological disease (and their doctors) should know that management is possible.

Relatives of people with existing incontinence might prove the most receptive and relevant audience to target with a prevention message. More research is needed to determine the most effective delivery of continence health education.

HEALTH PROFESSIONALS / RESEARCHERS

Health professionals would be well advised to incorporate this knowledge into their everyday clinical practice.

Patients and the general public could benefit from the dissemination of this knowledge.

We have identified many deficiencies in existing research data. There is a need to increase the quality of prevention research, to standardize terminology, and utilize prospective cohort designs for research. These improvements are necessary despite being both costly and time-consuming. Standardization of data acquisition, diagnostic methods, interviews, interventions and measurement are essential. This standardisation would be best coordinated through the International Continence Society. It is important that researchers fully understand the implications of different study designs, and what can and cannot be determined about causative links.

OTHER GROUPS

Government bodies, especially Health Departments, but also others including Departments of Education, Employment etc.

Health insurance companies or other health funders as appropriate in each country.

National organizations and societies whose members or target audience may have continence risks (such as organizations of people with neurological diseases), or whose members may have health care responsibilities for potentially incontinent people (doctors, nurses and other health professionals). Each group will need a message specifically targeted to their own areas of interest, to ensure they take an active role in prevention.

International organizations such as the International Continence Society (ICS), World Health Organization (WHO), International Consultation on Incontinence (Monaco 1998), and other health related organizations all need to work together to ensure a strong and consistent message is disseminated.

Industry. Companies which produce products to treat or manage incontinence should be encouraged to use their considerable communication channels to promote the prevention of incontinence.

THE FUTURE

PROMOTING CONTINENCE

The challenge for professionals will be the integration of this clinical evidence into practice and promoting and implementing these prevention strategies. More research is needed to supplement these initiatives.

This Consensus Statement has been published on behalf of all who would benefit from the implementation of PREVENTION strategies.

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CONFERENCE PARTICIPANTS

(cc) Conference Co-Chairs
(pc) Panel Chair
(pm) Panel Members
(s) Speakers
(pl) Planning Committee


Ted Arnold MD
Associate Professor
Department of Urology
Christchurch Hospital
Christchurch
New Zealand

Kari Bo PhD, PT
Associate Professor
Norwegian University of Sports & Physical Education
Oslo, Norway

Linda Brubaker MD (s)
Associate Professor
Department of Obstetrics & Gynecology
Rush Medical College;
Director - Urogynecology & Reconstructive Pelvic Surgery
Rush Presbyterian St. Luke's Medical Center
Chicago, Illinois, U.S.A.

Richard Bump MD (s)
Associate Professor and Chief
Division of Gynecologic Specialties
Duke University Medical Center
Durham, North Carolina, U.S.A.

Kathryn Burgio PhD (s)
Director - Continence Program
Division of Gerontology & Geriatric Medicine and Center for Aging
University of Alabama at Birmingham
Birmingham,Alabama, U.S.A.

Alan Cottenden PhD (pc)
Lecturer in Medical Physics
University College London
London, England

Ananias Diokno MD (s, pl)
Chief - Department of Urology
William Beaumont Hospital
Royal Oak Michigan, U.S.A.

Peter Dwyer MD
Associate Professor
Department of Obstetrics & Gynaecology
Fitzroy, Australia

David Fonda MD (s)
Associate Professor
Director, Aged Care Service Head,
Caulfield Continence Service
Caulfield General Medical Centre
Caulfield, Australia

Clare Fowler MD (s)
Consultant in UroNeurology
National Hospital for Neurology and Neurosurgery
London, England

Cheryle B. Gartley (cc, pl, pm)
President & Founder
The Simon Foundation for Continence
Wilmette, Illinois, U.S.A.

Derek Griffiths PhD (pm)
Urodynamics & Northern Alberta Continence Services
Misericordia Community Hospital & Health Centre
Edmonton, Alberta, Canada

Francine Grodstein ScD (s, pm)
Instructor of Medicine, Channing Laboratory
Department of Medicine
Brigham and Women's Hospital
Harvard Medical School
Boston, Massachusetts, U.S.A.

Sender Herschorn
MD Head, Division of Urology
Sunnybrook Health Science Centre;
Associate Professor
University of Toronto
Toronto, Ontario, Canada

Rudi Janknegt MD
Professor, Department of Urology
University of Maastricht
Maastricht, Netherlands

Steven Kaplan MD (s)
Professor and Vice-chairman
Department of Urology
College of Physicians and Surgeons
Columbia University
New York, New York, U.S.A.

Ruth Kirschner-Hermanns MD (s)
Research Fellow
Gerontology Division
Brigham and Women's Hospital
Harvard Medical School
Boston, Massachusetts, U.S.A.

Jo Laycock PhD, PT
The Culgaith Clinic
Culgaith, England

Gunnar Lose MD
Chief, Department of Obstetrics & Gynaecology
Glostrup, Denmark

Peter Lim MD
President
Society of Continence (Singapore);
Division of Urology
Toa Payoh Hospital
Toa Payoh, Singapore

Helmut Madersbacher MD
Associate Professor of Urology
Head of the Neuro-urology Unit
University Hospital
Innsbruck, Austria

Reverend Colin McLean (pm)
Chairman
Incontact
London, England

Richard Millard MD
Associate Professor
University of New South Wales;
Department of Urology
The Prince Henry Hospital
Sydney, Australia

Katherine Moore PhD
Assistant Professor
Faculty of Nursing
University of Alberta
Edmonton, Alberta, Canada

Kaoru Nishimura
President
Japan Continence Action Society
Tokyo, Japan

Christine Norton MA, RN (cc, pl, pm)
Nurse Specialist - Continence
Northwick Park & St. Mark's Hospital
Middlesex, England

Peggy Norton MD (s, pl)

Associate Professor
Head - Uro-gynecology & Pelvic Reconstructive Surgery
Salt Lake City, Utah, U.S.A.

Leroy Nyberg Jr. MD (pm)
Director Urology Programs
NIH/NIDDK/KUH
Bethesda, Maryland, U.S.A.

David Pollock BA
Director
The Continence Foundation
London, England

Neil Resnick MD (pl)

Chief of Gerontology
Brigham and Women's Hospital;
Associate Professor Harvard Medical School Boston,
Massachusetts, U.S.A.

Brenda Roe PhD, RN (pm)
Professor Institute of Human Aging
University of Liverpool
Liverpool, England

Ron Rozensky PhD (pl, pm)
Professor, Psychiatry & Behavioural Sciences
Northwestern University Medical School;
Associate Chairperson
Department of Psychiatry
Evanston Hospital
Evanston, Illinois, U.S.A.

Anita Saltmarche MHSc, RN (cc, s, pl)
President - Canadian Continence Foundation;
Clinical Associate - Faculty of Nursing
University of Toronto;
President - HealthCare Associates
Toronto, Ontario, Canada

Nigel Smith MD
Senior Clinical Research Fellow
Honorary Consultant
Faculty of Medicine
University of Leicester

Paul Smith PhD (s)
Clinical Psychologist
North Tyneside Health Care NHS Trust
North Tyneside, England

Stuart Stanton MD
Consultant - Urogynaecology
St. George's Hospital Urogynaecology Unit;
Chairman - The Continence Foundation
London, England

Eboo Versi MD
Department of Gynecology & Obstetrics
Brigham & Women's Hospital
Harvard Medical School
Boston, Massachusetts, U.S.A.

Thelma J. Wells PhD, RN (pm)
Helen Denne Schulte Nursing Professor
University of Wisconsin
Madison, Wisconson, U.S.A.

Don Wilson MD
Associate Professor
Department of Obstetrics & Gynaecology
University of Otago
Dunedin, New Zealand

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[Revised 4 April 2001]